Can you assign a Page Layout in a permission set? Required Editions and User Permissions
From the management settings for the appropriate object, go to Page Layouts or Record Types. Click Page Layout Assignment. Click Edit Assignment. Use the table to specify the page layout for each profile.
Can two users have the same profile? No, two profiles can not be assigned to the same user.
Can we assign crud permission on object by using permission set? Where you really have to struggle with permission sets is when you try to use them to add full access to an object and take profiles out of the equation. Adding CRUD permissions is easy through a permission set, but controlling full field-level security is more difficult.
How many Page Layouts can be assigned to a profile on a object? It’s important to note that you can only apply one page layout to one group of users per object, per record Type. For example, if you have one record Type on the Accounts object, you can only apply one page layout per profile.